Effective Role of Terminalia arjuna Reduced Gold Nanoparticles on Reproductive Dysfunction Induced by Acetaminophen in Male Wistar Rat

Abstract

Acetaminophen is a commonly used analgesic and antipyretic agent, which causes liver and kidney damage when it is taken in high doses. It also has an adverse effect on reproductive system. Terminalia arjuna has a beneficial effect on hepato-protective properties. In this study, effect of green synthesized gold nanoparticles using Terminalia arjuna (AuNPs) has been evaluated for prevention of reproductive disorder in male Wistar rats. Then, experiment was conducted on 24 healthy male Wistar rats. Biochemical test such as sperm count, sperm viability, seminal fructose level, testicular cholesterol, superoxide dismutase (SOD), catalase (CAT), and histopathological analysis revealed that co-administration of green synthesized AuNPs along with acetaminophen showed effective significant recovery in the reproductive disorder caused due to acetaminophen toxicity. Overall, the results emphasized the promising effect of green synthesized AuNPs against acetaminophen-induced toxicity in male Wistar rats.