Study of toxicity of bacillus thuringiensis cry protein isolated from 1953 strain of bacillus thuringiensis on the rat hepatic and renal tissues in a 90 day feed design

Abstract

Bacillus thuringiensis is a spore forming gram positive bacteria that have a number of different chemical compounds which are used for different types of insecticidal purposes. Though other various species of Bacillus are used for insecticidal purpose the effect on mammalian system has not been elaborated till now. In our study we observed some adverse effects of the cry toxins on the mammalian tissues i.e. specifically in the renal and hepatic tissues. The renal tissues and the hepatic tissues are the markers of toxin excretion and accumulation in physiological systems. Some results show no significant differences at all while some showed potent differences. Our study in brief reflects the different biochemical and histological changes that occurred by Bt Cry proteins in daily diet to the group of animals for observing the toxicological effects of the said insecticidal protein.