Please use this identifier to cite or link to this item: http://111.93.204.14:8080/xmlui/handle/123456789/626
Title: Review on: Short Hairpin Ribonucleic Acid (RNA)
Authors: Saruk Islam, Sk
Midya, Sujoy
Ganguly, Ram Kumar
Bhattacharya, Sayan
Keywords: RNA interference
siRNA
miRNA
shRNA
Gene silencing
Issue Date: 2018
Publisher: World Wide Journal of Multidisciplinary Research and Development
Abstract: RNA interference (RNAi), an accurate and potent gene silencing method, was first experimentally documented in 1998 in Caenorhabditis elegans by Fire et al. Subsequent RNAi studies have demonstrated that the clinical potential of synthetic small interfering RNAs (siRNAs), micro RNAs (miRNAs) and short hairpin RNAs shRNAs) used in various types of diseases such as cancer, neurodegenerative disorders and other metabolic diseases. siRNAs generally range from 21 to 25 base pairs (bp) in length and have sequence-homology-driven gene- knockdown capability. RNAi offers researchers an effortless tool for investigating biological systems by selectively silencing genes. Nevertheless, this area shows a huge potential for the pharmaceutical industry around the globe. Interestingly, recent studies have shown that the small RNA molecules, either indigenously produced as miRNAs) or exogenously administered synthetic dsRNAs, could effectively activate a particular gene in a sequence specific manner instead of silencing it. This novel phenomenon has been termed ‘RNA activation’ (RNAa). In this review, we analyze these research findings and discussed the function and applications of siRNAs, miRNAs, and shRNAs.
URI: http://111.93.204.14:8080/xmlui/handle/123456789/626
ISSN: 2454-6615
Appears in Collections:Articles

Files in This Item:
File Description SizeFormat 
Sujoy2.pdf980.94 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.