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Biological Impact of Feeding Rats with Cry Protein Based Diet

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dc.contributor.author Samanta, Tanushree Tulsian
dc.contributor.author Khamrai, Arpita Rani
dc.date.accessioned 2022-05-19T07:33:07Z
dc.date.available 2022-05-19T07:33:07Z
dc.date.issued 2021
dc.identifier.isbn 978-1-53618-959-9
dc.identifier.uri http://111.93.204.14:8080/xmlui/handle/123456789/620
dc.description.abstract Effect of Bt cry protein depends upon the concentration and length of exposure. The current study suggest that Bt cry protein ingestion induces a time dependent decreases in food intake capacity in treated rats through there is an increase in body weight. This work was conducted on the study of thebiological impact study on albino rats, with a range of combined parameters including Total protein & DNA fragmentatin to evaluate the impact of a cry protein based diet on animal health. The procedures were performed in the liver, kidney, and spleen, stomach tissues. The percentage of survival rate thus calculated, exhibited 100%survivability in both groups. Experimental researches in mice showed that DNA can persist in fragmented form in the gastrointestinal tract, penetrate the intestinal wall and reach the nuclei of leukocytes, spleen, liver cells. We studied the percentage of DNA fragmentation of isolated tissue (such liver, spleen, kidney stomach & blood) by DPA assay method and taking absorbance at 600nm by colorimetric method. It was observed that percentage of DNA fragmentation are higher in Bt cry protein treated rats as compared to control for stomach, kidney, liver tissue whereas lower value was obtained in spleen and blood samples. In addition, oxidative stress induction was observed in the stomach, kidney, liver after 90 days of infection initiation. The elevated DNA fragmentation may be related to increase oxidative stress. en_US
dc.language.iso en en_US
dc.publisher Nova Science Publishers ( Multidisciplinary Science and Advanced Technologies ) en_US
dc.subject Bacillus thuringiensis (Bt) en_US
dc.subject Cry protein en_US
dc.subject DNA Fragmentation en_US
dc.subject Colorimetric method en_US
dc.subject Oxidative stress en_US
dc.title Biological Impact of Feeding Rats with Cry Protein Based Diet en_US
dc.type Book chapter en_US


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