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Review on: Short Hairpin Ribonucleic Acid (RNA)

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dc.contributor.author Saruk Islam, Sk
dc.contributor.author Midya, Sujoy
dc.contributor.author Ganguly, Ram Kumar
dc.contributor.author Bhattacharya, Sayan
dc.date.accessioned 2022-06-20T07:20:15Z
dc.date.available 2022-06-20T07:20:15Z
dc.date.issued 2018
dc.identifier.issn 2454-6615
dc.identifier.uri http://111.93.204.14:8080/xmlui/handle/123456789/626
dc.description.abstract RNA interference (RNAi), an accurate and potent gene silencing method, was first experimentally documented in 1998 in Caenorhabditis elegans by Fire et al. Subsequent RNAi studies have demonstrated that the clinical potential of synthetic small interfering RNAs (siRNAs), micro RNAs (miRNAs) and short hairpin RNAs shRNAs) used in various types of diseases such as cancer, neurodegenerative disorders and other metabolic diseases. siRNAs generally range from 21 to 25 base pairs (bp) in length and have sequence-homology-driven gene- knockdown capability. RNAi offers researchers an effortless tool for investigating biological systems by selectively silencing genes. Nevertheless, this area shows a huge potential for the pharmaceutical industry around the globe. Interestingly, recent studies have shown that the small RNA molecules, either indigenously produced as miRNAs) or exogenously administered synthetic dsRNAs, could effectively activate a particular gene in a sequence specific manner instead of silencing it. This novel phenomenon has been termed ‘RNA activation’ (RNAa). In this review, we analyze these research findings and discussed the function and applications of siRNAs, miRNAs, and shRNAs. en_US
dc.language.iso en en_US
dc.publisher World Wide Journal of Multidisciplinary Research and Development en_US
dc.subject RNA interference en_US
dc.subject siRNA en_US
dc.subject miRNA en_US
dc.subject shRNA en_US
dc.subject Gene silencing en_US
dc.title Review on: Short Hairpin Ribonucleic Acid (RNA) en_US
dc.type Article en_US


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