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Synthesis, in vitro evaluation of antibacterial, antifungal and larvicidal activities of pyrazole/pyridine based compounds and their nanocrystalline MS (M = Cu and Cd) derivatives

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dc.contributor.author Mondal, Gopinath
dc.contributor.author Jana, Harekrishna
dc.contributor.author Acharjya, Moumita
dc.contributor.author Santra, Ananyakumari
dc.contributor.author Bera, Pradip
dc.contributor.author Jana, Abhimanyu
dc.contributor.author Panja, Anangamohan
dc.contributor.author Bera, Pulakesh
dc.date.accessioned 2022-06-20T11:08:36Z
dc.date.available 2022-06-20T11:08:36Z
dc.date.issued 2017-08
dc.identifier.issn 1054-2523
dc.identifier.issn 1554-8120
dc.identifier.uri http://111.93.204.14:8080/xmlui/handle/123456789/629
dc.description.abstract Methyl 3,5-dimethyl pyrazole-1-dithioate (mdpa) (1), benzyl 3,5-dimethyl pyrazole-1-dithioate (bdpa) (2), 3,5- dimethylpyrazole-1-(5methyl-1H-pyrazol-3-ylmethyl)- 1H-pyrazole (3), copper(II)-mdpa (4), copper(II)-bdpa (5), cadmium(II)-mdpa (6), cadmium(II)-bdpa (7), Cu2S nanoparticles (8 and 9) derived from 4 and 5, respectively, CdS nanoparticles (10 and 11) derived from 6 and 7, respectively, were synthesized to screen their antimicrobial activities. Prolonged reaction with CuCl2.2H2O and 3 followed by addition of trace amount of pyridine furnished a crystalline chloro bridged complex [Cu(μ-Cl)2(pyridine)2]n and its structure was solved by single X-ray crystallography. Antibacterial activities of all of the synthesized materials (1–12) were evaluated against Gram positive bacteria including Staphylococcus aureus and Bacillus subtilis and Gram negative bacteria including Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae and Proteus vulgaris. Fungi (Candida albicans, Aspergillus flavus) were also used to test antifungal activities with the compounds. Present study revealed that 8 shows best antibacterial activity among the present reported compounds. An excellent antifugal activity is shown by 12 emerging to be a better antibiotic than standard fluconazole. Besides fungicidal effect, 12 has promising larvicidal effect. The structure and activity relationship has been discussed. en_US
dc.language.iso en en_US
dc.publisher Medicinal Chemistry Research (Springer) en_US
dc.subject Antibacterial en_US
dc.subject Antifungal en_US
dc.subject Larvicidal en_US
dc.subject Pyrazole/Pyridine complexes en_US
dc.subject Nanoparticles en_US
dc.title Synthesis, in vitro evaluation of antibacterial, antifungal and larvicidal activities of pyrazole/pyridine based compounds and their nanocrystalline MS (M = Cu and Cd) derivatives en_US
dc.type Article en_US


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