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Methicillin-resistant S. aureus in Eastern India: Some Molecular Epidemiological Perspectives

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dc.contributor.author Bhattacharyya, Chandrima
dc.contributor.author Dey, Rupali
dc.contributor.author Roy, Tamanna
dc.contributor.author Ghosh, Abhrajyoti
dc.contributor.author Jana, Harekrishna
dc.date.accessioned 2022-07-16T06:39:11Z
dc.date.available 2022-07-16T06:39:11Z
dc.date.issued 2017-02
dc.identifier.issn 2321-6379
dc.identifier.issn 2321-595X
dc.identifier.uri http://111.93.204.14:8080/xmlui/handle/123456789/687
dc.description.abstract Background: Staphylococcus aureus is the most important nosocomial pathogen causing skin and soft tissue infection. Methicillin-resistant S. aureus (MRSA) is now established in both community-acquired and hospital-acquired infections. The defining feature of MRSA is the staphylococcal cassette chromosome mec (SCCmec), which is a mobile genetic element, carrying the central determinant for broad-spectrum beta-lactam antibiotic resistance encoded by the mecA gen, whereas the presence of panton-valentine leukocidin (PVL) gives more virulence to the MRSA. Aim: To assess molecular epidemiology of MRSA in Eastern India. Design: Descriptive cross-sectional study. Materials and Methods: In this study, from 940 samples in a tertiary care hospital in rural India, over 6 months, 20 MRSA isolates were identified. These isolates were typed to study the diversity in the structures of SCCmec elements and ccr types. Statistical analysis was performed by SPSS software. Results: Isolates carrying SSCmec Type IV were found to be dominant (60%), whereas a small proportion was SSCmec Type V (10%). Some composite strains were found. PVL gene was found to be associated with community-associated MRSA (CA-MRSA) genotypes. Conclusion: Genotypical blurring of CA-MRSA and hospital-acquired MRSA was seen. Composite SCCmec strains found showing need for new nomenclature methods. en_US
dc.language.iso en en_US
dc.publisher International Journal of Scientific Study en_US
dc.subject Epidemiological typing en_US
dc.subject Methicillin-resistant Staphylococcus aureus en_US
dc.subject Staphylococcal cassette chromosome en_US
dc.title Methicillin-resistant S. aureus in Eastern India: Some Molecular Epidemiological Perspectives en_US
dc.type Article en_US


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