dc.contributor.author |
Bhattacharyya, Chandrima |
|
dc.contributor.author |
Dey, Rupali |
|
dc.contributor.author |
Roy, Tamanna |
|
dc.contributor.author |
Ghosh, Abhrajyoti |
|
dc.contributor.author |
Jana, Harekrishna |
|
dc.date.accessioned |
2022-07-16T06:39:11Z |
|
dc.date.available |
2022-07-16T06:39:11Z |
|
dc.date.issued |
2017-02 |
|
dc.identifier.issn |
2321-6379 |
|
dc.identifier.issn |
2321-595X |
|
dc.identifier.uri |
http://111.93.204.14:8080/xmlui/handle/123456789/687 |
|
dc.description.abstract |
Background: Staphylococcus aureus is the most important nosocomial pathogen causing skin and soft tissue infection. Methicillin-resistant S. aureus (MRSA) is now established in both community-acquired and hospital-acquired infections. The defining feature of MRSA is the staphylococcal cassette chromosome mec (SCCmec), which is a mobile genetic element, carrying the central determinant for broad-spectrum beta-lactam antibiotic resistance encoded by the mecA gen, whereas the presence of panton-valentine leukocidin (PVL) gives more virulence to the MRSA. Aim: To assess molecular epidemiology of MRSA in Eastern India. Design: Descriptive cross-sectional study. Materials and Methods: In this study, from 940 samples in a tertiary care hospital in rural India, over 6 months, 20 MRSA isolates were identified. These isolates were typed to study the diversity in the structures of SCCmec elements and ccr types. Statistical analysis was performed by SPSS software. Results: Isolates carrying SSCmec Type IV were found to be dominant (60%), whereas a small proportion was SSCmec Type V (10%). Some composite strains were found. PVL gene was found to be associated with community-associated MRSA (CA-MRSA) genotypes. Conclusion: Genotypical blurring of CA-MRSA and hospital-acquired MRSA was seen. Composite SCCmec strains found showing need for new nomenclature methods. |
en_US |
dc.language.iso |
en |
en_US |
dc.publisher |
International Journal of Scientific Study |
en_US |
dc.subject |
Epidemiological typing |
en_US |
dc.subject |
Methicillin-resistant Staphylococcus aureus |
en_US |
dc.subject |
Staphylococcal cassette chromosome |
en_US |
dc.title |
Methicillin-resistant S. aureus in Eastern India: Some Molecular Epidemiological Perspectives |
en_US |
dc.type |
Article |
en_US |