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Synthesis of a new pyridinyl thiazole ligand with hydrazone moiety and its cobalt(III) complex: X-ray crystallography, in vitro evaluation of antibacterial activity

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dc.contributor.author Bera, Pradip
dc.contributor.author Brandao, Paula
dc.contributor.author Mondal, Gopinath
dc.contributor.author Jana, Harekrishna
dc.contributor.author Jana, Abhimanyu
dc.contributor.author Santra, Ananyakumari
dc.contributor.author Bera, Pulakesh
dc.date.accessioned 2022-07-18T10:06:34Z
dc.date.available 2022-07-18T10:06:34Z
dc.date.issued 2017
dc.identifier.issn 0277-5387
dc.identifier.uri http://111.93.204.14:8080/xmlui/handle/123456789/695
dc.description.abstract The present work report the synthesis, structural characterization and in vitro antibacterial studies of 4-(4- methoxy phenyl)-2-(2-(1-pyridine-2-yl)ethylidene) hydrazinyl)thiazole bromide (HL∙Br) and its cobalt(III) complex, [CoL2]ClO4. HL∙Br crystallizes in a space group Pbca in a nearly planar structure and the crystal structure of complex shows a CoIIIN6 coordination geometry in which each L shows N,N,N-donor binding modes. Solution magnetic susceptibility measurement of [CoL2]ClO4 by modified Evan’s method confirms the low spin diamagnetic nature of the cobalt(III) complex. New compounds were screened for their antibacterial studies against gram positive bacteria including Staphylococcus aureus, Streptococcus fecalis and Bacillus and gram-negative bacteria including Escherichia coli, Pseudomonas aeruginosa, Salmonella Typhi, Klebsiella and Proteus vulgaris. Both the compounds show very stronger growth inhibition activity against gram negative bacteria than gram positive bacteria. Present study shows that HL∙Br has maximum antibacterial activity E.coli (25±0.2 mm) and S.typhi (28±0.7 mm) at an MIC of 200 µg/mL and 50 µg/mL respectively, showing greater MIC values than the standard antibiotic ciprofloxacin (8 µg/mL against E.coli and 10 µg/mL against S.typhi). en_US
dc.language.iso en en_US
dc.publisher Polyhedron en_US
dc.subject Thiazole en_US
dc.subject Hydrazone en_US
dc.subject Co(III)complex en_US
dc.subject Crystallography en_US
dc.subject Antibacterial activity en_US
dc.title Synthesis of a new pyridinyl thiazole ligand with hydrazone moiety and its cobalt(III) complex: X-ray crystallography, in vitro evaluation of antibacterial activity en_US
dc.type Article en_US


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